Both equations have been validated extensively in Caucasian and African American populations with impaired kidney function (eGFR 60 mL/min/1.73 m 2 compared to the MDRD Study equation however, the influence of imprecision of creatinine assays on the uncertainty of an eGFR value is greater at higher eGFR values and should be considered when assessing eGFRs > 60 mL/min/1.73 m 2. The MDRD Study and CKD-EPI equations are the most widely used and thoroughly validated equations.Because the MDRD and CKD-EPI equations employ age, gender, and race, providers may observe that CKD is present despite a serum creatinine concentration that appears to fall within or just above the normal reference range.
The normal serum creatinine reference range does not necessarily reflect a normal GFR for a patient.Both the MDRD Study and CKD-EPI equations include variables to account for serum creatinine variation with age, gender, and race. Age, gender, and race all affect muscle mass and, in turn, serum creatinine. GFR is related inversely and nonlinearly to serum creatinine. GFR is poorly inferred from serum creatinine alone.NIDDK also encourages clinical laboratories to routinely estimate GFR and report the value when serum creatinine is measured for patients 18 and older, when appropriate and feasible. Reasons for Using the MDRD Study or CKD-EPI Equation to Estimate GFRīecause mild and moderate kidney injury is poorly inferred from serum creatinine alone, NIDDK strongly recommends the use of either the MDRD Study or CKD-EPI equation to estimate GFR from serum creatinine in adults. Patients under the age of 18: Calculate eGFR using the Schwartz equation for patients under age 18.Ĭaution: It is important to know the method used to measure creatinine in a blood, serum, or plasma sample, as it will affect the formula for estimating GFR in children.ĭetermine which calculator to use. eGFR should be used with caution in acutely ill or hospitalized patients who may exhibit rapidly changing kidney function.Īdults: Use either the Modification of Diet in Renal Disease (MDRD) Study equation or the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Use of any serum creatinine-based estimate requires that kidney function be at a steady state. Scys is the level of standardized serum cystatin C in mg/L Calculate estimated GFR (eGFR) from serum creatinine levels to assess kidney function.BUN is the level of blood urea nitrogen in mg/dL.a is a coefficient dependent on sex: 1 for females, 1.076 for males.It is an excellent confirmatory test, too. This test uses both creatinine and cystatin C indicators.
Creatinine-Cystatin C-based CKiD equation (2012)
0 kommentar(er)
